Pair Name	Rosmarinic acid, Indoleamine 2,3-dioxygenase 1
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Up-regulation	Expression	IFNG	hsa3458
	Up-regulation	Expression	IL2	hsa3558
	Down-regulation	Expression	TNF	hsa7124
	Down-regulation	Expression	IL10	hsa3586
In Vivo Model	The H22 cells were inoculated into the peritoneal cavity of the mice. After three passages in cell ascites, the ascites was extracted and diluted to the concentration of 1.5×10⁷/ml with normal saline. The H22 cell suspension (3×106 cell /mouse) was subcutaneously injected into the right side of the axillary of mice.
Result	The mechanism might be related to regulating immune response and immunocytokines, as well as alleviating immunosuppression induced by Tregs in the tumor immune microenvironment.